WebFBXO38 is an E3 ligase of PD-1 that mediates Lys48-linked poly-ubiquitination and subsequent proteasome degradation. Conditional knockout of Fbxo38 in T cells did not … WebMay 2, 2024 · FBXO38 is an E3 ligase of PD-1 that mediates Lys48-linked poly-ubiquitination and subsequent proteasome degradation. ... These data indicate that FBXO38 regulates PD-1 expression and highlight an ...
FBXO38 mediates PD-1 ubiquitination and regulates anti …
WebMar 12, 2024 · Project 25 Phase II. Atlanta Public Schools Police operate on the City of Atlanta P25 system. Fulton County Services DMR. DMR Motorola Capacity Plus Multi … WebDec 1, 2024 · FBXO38 is an E3 ligase of PD-1 that mediates Lys48-linked poly-ubiquitination and subsequent proteasome degradation. Conditional knockout of Fbxo38 in T cells did not affect T cell receptor and ... from day one logo
Immune checkpoint signaling and cancer immunotherapy
WebAug 10, 2024 · Anti-PD-1 antibody and control antibody were administrated at day 6, day 9, and day 12 after tumor inoculation. ... Guo X, Jiang S, Chen T, Hu Z, et al. FBXO38 Mediates PD-1. Ubiquitination and ... WebOct 27, 2024 · It has been reported that FBXO38 targets PD-1 on the cell surface for proteasome pathway degradation after PD-1 internalization, ... X. Meng et al., FBXO38 … For human and mouse T cell activation, anti-mouse CD3ε (clone 145-2C11) and anti-mouse CD28 (clone 37.51) were purchased from Biolegend, anti-human CD3ε (clone UCHT-1) and anti-human CD28 (clone CD28.2) were from eBioscience. For the flow cytometry analysis, anti-mouse CD8 (clone 53-6.7), anti-mouse … See more Blood samples and colorectal carcinoma tissues of patients were obtained at Nanfang Hospital, Guangzhou, China. Blood samples and hepatocellular carcinoma tissues of patients were obtained at … See more Human PDCD1 and FBXO38 genes were amplified from the Jurkat cell cDNA library and subsequently cloned into PHAGE expression vectors … See more Human PBMCs were donated by healthy laboratory members. HEK293FT cells were provided by the laboratory of L. Hui (Shanghai Institute of Biochemistry and Cell Biology). The B16F10 cell line was originally obtained … See more Total RNA was extracted with TRIzol (Life Technologies) from the indicated cells and subjected to RT–qPCR using gene-specific primers. … See more from day dot nappy bag