WitrynaCompared to that of the Blank group, the phenotype of IMQ-treated mice was significantly exacerbated, suggesting that the IMQ-induced psoriasis mouse model was successfully constructed. Moreover, the erythema and scales of the mice treated with K17 siRNA alone or in combination were significantly decreased compared to those of … WitrynaThese models assisted in broadening the understanding of the pathogenesis, disease mechanism, and preclinical drug treatment efficacy of psoriasis. Among these murine models, the IMQ-induced psoriasis-like dermatitis model has been highly utilized for drug discovery . IMQ is a Toll-like receptor (TLR) 7/8 ligand that is a strong activator of ...
IMQ induced psoriasis-like models JIR
WitrynaImiquimod (IMQ) Induced Psoriasis Psoriasis is a common skin disorder characterized by focal formation of inflamed, raised plaques that shed scales from excessive growth … Witryna4 sty 2024 · Psoriasis is a common inflammatory skin disorder, which can be associated with psychological disorders, such as anxiety and depression. This study investigated the efficacy and the mechanism of action of a natural compound coptisine using imiquimod (IMQ)-induced psoriasis mice. Coptisine reduced the severity of psoriasis-like skin … high low chips
Tenascin C+ papillary fibroblasts facilitate neuro-immune …
Witryna15 paź 2024 · The IMQ-induced differentiated HaCaT in vitro model recapitulated some aspects of the psoriasis pathogenesis similar to murine model. … WitrynaIMQ-induced psoriasis rodent models Imiquimod (IMQ), an immune activator and also a ligand of toll-like receptor (TLR) 7 and 8, is used for topical treatment of genital and … Witryna9 lip 2024 · Moreover, low levels of CEBPD in the imiquimod‑induced mouse model of psoriasis were restored by shikonin treatment, which ameliorated excessive keratinocyte proliferation. Taken together, these findings suggest that CEBPD plays a key role in the pathogenesis of psoriasis and can be targeted by shikonin as a potential therapeutic … high low chiffon bridesmaid dresses