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Nphs2 cre

Web29 apr. 2024 · The phenotypes of extrarenal Cre activity were more pronounced than that of NPHS2-Cre, but DNA damage and epithelial apoptosis appear to be common Cre … Web21 feb. 2024 · Tg (NPHS2-cre)295Lbh. Mutation details : The human NPHS2 promoter, including the entire 5' untranslated region, was used to drive cre recombinase …

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WebNPHS2 pathogenic variants are the most common podocyte gene defects. Yet, pathogenic variants are found only in a minority of SRNS patients. No homozygotes or compound heterozygotes were observed in 377 biopsy confirmed late-onset FSGS [52].In three large worldwide analyses, NPHS2 pathogenic variants were found in roughly 10% of the … Web1 jan. 2003 · Although the NPHS2-Cre transgenic mouse line has been used for conditional knock-out in podocytes for over 15 years (Moeller et al., 2003), the first report of its toxicity in these cells was... day of the tread bike ride 2021 https://cafegalvez.com

Podocyte-specific expression of Cre recombinase promotes

Web24 jul. 2012 · The Nphs2-Cre mouse line (3) expresses Cre-recombinase tran-script under control of a 2.5-kb mouse podocyte-specific podocin promoter. The Arnt flox/flox mice were kindly provided by Dr. Frank J. Gonzalez (22). To generate mice with podocyte-selective deletion of Arnt, Nphs2-Cre mice were bred to Arnt flox/flox homozygotes. Web19 mrt. 2024 · NPHS2-Cre +/-, Tsc2 wt/wt mice (Nphs2-Cre) and NPHS2-Cre-/-, Tsc2 flox/flox mice (Tsc2 flox/flox) were used as controls. F, flox; +, wt. ( B ) Primary cultured … Web13 apr. 2024 · Due to the podocyte-specific action of the Nphs2 (podocin) promoter-triggered Cre-recombinase, the stop cassette was removed and mWT- or mI93M-UCH-L1 overexpression on glomerular podocytes was ... gaylord family stadium capacity

大鼠模型基因编辑，手术模型，繁育服务，表型分析一站式解决方 …

Category:Construction of a Viral T2A-peptide Based Knock-In Mouse Model …

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Nphs2 cre

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WebTools. Data Hub. Learn more about Addgene materials from user-contributed reports describing AAV and antibody experiments. Sequence Analyzer. Basic analysis for a user-entered sequence; includes restriction sites and map Web1 aug. 2024 · Cre 工具鼠的种类及应用 Cre 工具鼠主要分为 3 类：全身性 Cre、组织特异性 Cre 和配体或药物诱导 Cre。 全身性 Cre：通过诱导剂来调节驱动 Cre 重组酶的启动子活 …

Nphs2 cre

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Web20 aug. 2015 · Next, we asked whether the protection from podocyte loss in diabetic NPHS2 cre Notch1 F/F mice could be related to the effect of Notch1 on podocyte apoptosis. We … WebFirst, Nphs2 encodes podocin, an essential component of the slit diaphragm, a cell-cell junctional structure between adjacent podocytes, which is one of the most important …

WebPartial Sequences from Addgene (3) Addgene has sequenced portions of this plasmid for verification. The results are shown below. Leading primers are indicated on the first line … Web1 mrt. 2024 · Of these significant, differentially regulated genes, 139 were up-regulated and 91 were down-regulated in glomeruli of NPHS2-Cre +/+ mice as compared with that …

WebPartial Sequences from Addgene (3) Addgene has sequenced portions of this plasmid for verification. The results are shown below. Leading primers are indicated on the first line of each sequence. Analyze Sequence. Web7 sep. 2024 · The CD16/7-nephrin activation model allows for precisely-timed induction of nephrin tyrosine phosphorylation in live cells by addition of specific antibodies that cluster the extracellular CD16 domain and results in intracellular tyrosine phosphorylation of nephrin’s cytoplasmic tail.

Web5 apr. 2014 · 肾小管组织特异性cre工具鼠目前已应用于肾小管基因敲除的cre工具鼠主要由以下启动子驱动，其中在近端小管中特异性较高的启动子为GGT，SGLT2，PEPCKKAP， …

Web在Nphs2基因目的exons两侧分别插入loxP位点。该flox小鼠可与组织特异性Cre工具鼠交配，获得在特定 细胞类型或组织中敲除Nphs2基因的小鼠模型。 疾病预测 肾病综合征 Nephrotic Syndrome 近似模型的表型 MGI:4847559 注：该品系与CAG-cre工具鼠交配才可能获得预 期表型 day of the triffids 1962 blu rayWeb7 aug. 2024 · 2.1 新的Cre品系需要做的四件事：. 1) 了解小鼠来源，背景信息及发表的文章；. 2) 建立基因型鉴定方法，确认小鼠正确；. 3) 验证Cre在目标组织中的表达. 4) 验 … day of the triffids 1951WebThe NPHS2 gene provides instructions for making a protein called podocin. Podocin is primarily found in the kidneys, which are organs that filter waste products from the blood … gaylord family - oklahoma memorial stadiumhttp://www.labmodel.cn/mod_product-view-p_id-4397.html day of the triffids 1962 castWebThe p2.5P-Cre transgene was designed with a 2.5 kb fragment of the human podocin (or NPHS2) promoter/enhancer region upstream of a Cre recombinase cassette followed by a murine protamine poly-adenylation signal. The donating investigator reports that the transgene was microinjected into (C57BL/6 X SJL)F2 mouse eggs. gaylord feenyWebNphs2-CreERT2 品系全名 C57BL/6JSmoc- Nphs2tm1 (IRES-CreERT2)Smoc 目录号 NM-KI-00128 品系状态 胚胎冻存 加入购物车 导出PDF 基因信息 基因名 Nphs2 基因曾用名 … day of the triffids 1962 dvdWeb7 sep. 2024 · ARF6-flox mice with LoxP sites flanking exon 1 and 2 were crossed with Cre mice in which Cre recombinase was driven by the podocyte-specific podocin promoter … day of the triffid